A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

Author Pacheco, Murilo Santos Autor UNIFESP Google Scholar
Barbieri, Douglas Autor UNIFESP Google Scholar
Silva, Classius Ferreira da Autor UNIFESP Google Scholar
Moraes, Mariana Agostini de Autor UNIFESP Google Scholar
Abstract In recent years, orally disintegrating films (ODFs) have been studied as alternative ways for drug administration. They can easily be applied into the mouth and quickly disintegrate, releasing the drug with no need of water ingestion and enabling absorption through the oral mucosa. The ODFs matrices are typically composed of hydrophilic polymers, in which the natural polymers are highlighted since they are polymers extracted from natural sources, non-toxic, biocompatible, biodegradable, and have favorable properties for this application. Besides that, natural polymers such as polysaccharides and proteins can be applied either alone or blended with other synthetic, semi-synthetic, or natural polymers to achieve better mechanical and mucoadhesive properties and fast disintegration. In this review, we analyzed ODFs developed using natural polymers or blends involving natural polymers, such as maltodextrin, pullulan, starch, gelatin, collagen, alginate, chitosan, pectin, and others, to overview the recent publications and discuss how natural polymers can influence ODFs properties.
Keywords Orodispersible film
Fast dissolving film
Oral strip
Casting
Disintegration time
Film-forming agent
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2018/25656-0
CNPq: 308994/2017-5
Date 2021-05-01
Published in PACHECO, Murilo Santos; BARBIERI, Douglas; SILVA, Classius Ferreira da; MORAES, Mariana Agostini de. A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others. International Journal of Biological Macromolecules, v. 78, p. 504-513, 2021. ISSN 0141-8130. DOI: 10.1016/j.ijbiomac.2021.02.180
ISSN 0141-8130 (Sherpa/Romeo)
Publisher Elsevier
Extent 504-513
Origin https://doi.org/10.1016/j.ijbiomac.2021.02.180
Access rights Closed access
Type Article
URI https://repositorio.unifesp.br/handle/11600/60294

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