First-time Isolation of Flavonoids and Cytotoxic Potential of the Amazonian Shrub Ptychopetalum olacoides Benth

Dutra, Karen Danielle Borba; Macedo, Arthur Ladeira; Montenegro, Raquel Carvalho; Jimenez, Paula Christine [UNIFESP]; Castro, Rosane Nora; Epifânio, Rosangela de Almeida; Vasconcelos, Thatyana Rocha Alves; Valverde, Alessandra Leda

First-time Isolation of Flavonoids and Cytotoxic Potential of the Amazonian Shrub Ptychopetalum olacoides Benth

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WOS000432051300011.pdf(279.34 KB)

Data

2017

Autores

Dutra, Karen Danielle Borba

Macedo, Arthur Ladeira

Montenegro, Raquel Carvalho

Jimenez, Paula Christine

Castro, Rosane Nora

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Tipo

Artigo

Resumo

In the present study, three flavonoids, 3-O-methylquercetin (1), 3,4'-O-dimethylquercetin (2) and 3,7-O-dimethylquercetin (3) were isolated and characterized for the first time from a methanol extract obtained from the species Ptychopetalum olacoides. The structures of compounds were identified by spectroscopic methods (1D-, 2D-NMR, MS and UV) and confirmed by comparison with the respective literature data. The cytotoxic effect of crude extract was evaluated in vitro against three human cancer cell lines. The results showed a mild cytotoxic activity (IC50 = 45.16 mu g/mL) against breast cancer (MCF-7). However, crude extract did not exhibit any cytotoxic effect against normal cell human fibroblast (MRC-5).

Citação

Revista Virtual De Quimica. Niteroi, v. 9, n. 6, p. 2299-2304, 2017.