First-time Isolation of Flavonoids and Cytotoxic Potential of the Amazonian Shrub Ptychopetalum olacoides Benth

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dc.citation.issue6
dc.citation.volume9
dc.contributor.authorDutra, Karen Danielle Borba
dc.contributor.authorMacedo, Arthur Ladeira
dc.contributor.authorMontenegro, Raquel Carvalho
dc.contributor.authorJimenez, Paula Christine [UNIFESP]
dc.contributor.authorCastro, Rosane N.
dc.contributor.authorEpifânio, Rosangela de Almeida
dc.contributor.authorVasconcelos, Thatyana Rocha Alves
dc.contributor.authorValverde, Alessandra Leda
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageNiteroi
dc.date.accessioned2020-07-17T14:03:17Z
dc.date.available2020-07-17T14:03:17Z
dc.date.issued2017
dc.description.abstractIn the present study, three flavonoids, 3-O-methylquercetin (1), 3,4'-O-dimethylquercetin (2) and 3,7-O-dimethylquercetin (3) were isolated and characterized for the first time from a methanol extract obtained from the species Ptychopetalum olacoides. The structures of compounds were identified by spectroscopic methods (1D-, 2D-NMR, MS and UV) and confirmed by comparison with the respective literature data. The cytotoxic effect of crude extract was evaluated in vitro against three human cancer cell lines. The results showed a mild cytotoxic activity (IC50 = 45.16 mu g/mL) against breast cancer (MCF-7). However, crude extract did not exhibit any cytotoxic effect against normal cell human fibroblast (MRC-5).en
dc.description.affiliationUniv Fed Fluminense, Inst Quim, Dept Quim Organ, Campus Valonguinho, BR-24020141 Niteroi, RJ, Brazil
dc.description.affiliationUniv Fed Para, Inst Ciencias Biol, BR-66075110 Belem, Para, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Mar, BR-11070100 Santos, SP, Brazil
dc.description.affiliationUniv Fed Rural Rio de Janeiro, Dept Quim, BR-23897000 Seropedica, RJ, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Mar, BR-11070100 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPERJ
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2299-2304
dc.identifierhttps://dx.doi.org/10.21577/1984-6835.20170137
dc.identifier.citationRevista Virtual De Quimica. Niteroi, v. 9, n. 6, p. 2299-2304, 2017.
dc.identifier.doi10.21577/1984-6835.20170137
dc.identifier.fileWOS000432051300011.pdf
dc.identifier.issn1984-6835
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55280
dc.identifier.wosWOS:000432051300011
dc.language.isoeng
dc.publisherBrazilian Chemical Soc
dc.relation.ispartofRevista Virtual De Quimica
dc.rightsAcesso aberto
dc.subjectAntitumoren
dc.subjectCanceren
dc.subjectFlavonoidsen
dc.subjectOlacaceaeen
dc.subjectP. olacoidesen
dc.titleFirst-time Isolation of Flavonoids and Cytotoxic Potential of the Amazonian Shrub Ptychopetalum olacoides Benthen
dc.typeArtigo
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