Estudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótons

dc.contributor.advisorSilva, Magnus Regios Dias da [UNIFESP]
dc.contributor.advisorLatteshttp://lattes.cnpq.br/2598816440086436
dc.contributor.authorSantos, Livia Marcela dos [UNIFESP]
dc.contributor.authorLatteshttp://lattes.cnpq.br/2305144569495023
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.coverage.spatialSão Paulo
dc.date.accessioned2019-06-19T14:58:22Z
dc.date.available2019-06-19T14:58:22Z
dc.date.issued2017-01-31
dc.description.abstractPurpose: Magnesium is an important electrolyte for all cell functions and its imbalance may lead to a large spectrum of diseases. Clinical case of hypomagnesemia diagnosed at the emergency due to chronic use of Proton Pump Inhibitor (PPI), which were excluded other magnesium deficiency causes. PPIs are drugs widely used in medical practice, and many cases of PPIs causing hypomagnesemia have been described. Our aim was to diagnosis and monitor the clinical and electrolyte findings during recovery from hypomagnesemia. Results: A female using omeprazole for 10 years presented with arrhythmia and severe hypomagnesemia. Laboratory tests revealed magnesium 0.6 mg/dL (NR: 1.5 to 2.5 mg/dL), calcium 7.3 mg/dL (NR: 8.5 to 10.2 mg/dL), parathyroid hormone (PTH) 13.3 pg/mL (NR: 15 to 65 pg/mL), and low urinary magnesium excretion. Her electrocardiography test disclosed typical prolonged QT interval and U waves. We discuss differential diagnoses, pathophysiology, and the reversibility of symptoms after effective treatment. Conclusion: We emphasize that even in mostly asymptomatic very long¬term PPI users, one can go to life-threatening arrhythmias.en
dc.description.sourceDados abertos - Sucupira - Teses e dissertações (2017)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent75 f.
dc.identifierhttps://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4991919pt_BR
dc.identifier.citationSantos, Livia Marcela dos. Estudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótons. 2016. 75 f. Dissertação (Mestrado em Medicina: Endocrinologia Clínica) – Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2016.
dc.identifier.fileLívia Marcela dos Santos - PDF A.pdf.pdf
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/50752
dc.language.isopor
dc.publisherUniversidade Federal de São Paulo (UNIFESP)
dc.rightsAcesso aberto
dc.subjectProton Pump Inhibitorsen
dc.subjectInibidores da Bomba de Prótonspt_BR
dc.subjectMetabolic Diseasesen
dc.subjectDoenças Metabólicaspt_BR
dc.subjectMagnesiumen
dc.subjectMagnésiopt_BR
dc.titleEstudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótonspt_BR
dc.typeinfo:eu-repo/semantics/masterThesis
unifesp.campusSão Paulo, Escola Paulista de Medicinapt_BR
unifesp.graduateProgramMedicina (Endocrinologia Clínica)pt_BR
unifesp.knowledgeAreaEndocrinologia Básicapt_BR
unifesp.researchAreaBases Moleculares Das Doenças Endócrino-Metabólicasppt_BRt
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