Estudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótons
Data
2017-01-31
Autores
Santos, Livia Marcela dos 
Orientadores
Silva, Magnus Regios Dias da
Tipo
Dissertação de mestrado
Título da Revista
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Resumo
Purpose: Magnesium is an important electrolyte for all cell functions and its imbalance may lead to a large spectrum of diseases. Clinical case of hypomagnesemia diagnosed at the emergency due to chronic use of Proton Pump Inhibitor (PPI), which were excluded other magnesium deficiency causes. PPIs are drugs widely used in medical practice, and many cases of PPIs causing hypomagnesemia have been described. Our aim was to diagnosis and monitor the clinical and electrolyte findings during recovery from hypomagnesemia. Results: A female using omeprazole for 10 years presented with arrhythmia and severe hypomagnesemia. Laboratory tests revealed magnesium 0.6 mg/dL (NR: 1.5 to 2.5 mg/dL), calcium 7.3 mg/dL (NR: 8.5 to 10.2 mg/dL), parathyroid hormone (PTH) 13.3 pg/mL (NR: 15 to 65 pg/mL), and low urinary magnesium excretion. Her electrocardiography test disclosed typical prolonged QT interval and U waves. We discuss differential diagnoses, pathophysiology, and the reversibility of symptoms after effective treatment. Conclusion: We emphasize that even in mostly asymptomatic very long¬term PPI users, one can go to life-threatening arrhythmias.
Descrição
Citação
Santos, Livia Marcela dos. Estudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótons. 2016. 75 f. Dissertação (Mestrado em Medicina: Endocrinologia Clínica) – Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2016.