ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

Segreto, Helena Regina Comodo [UNIFESP]; Segreto, Roberto Araujo [UNIFESP]; Thomaz, K.; Silva, MRR; Novo, Neil Ferreira [UNIFESP]

ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

Data

1994-03-01

Autores

Segreto, Helena Regina Comodo

Segreto, Roberto Araujo

Thomaz, K.

Silva, MRR

Novo, Neil Ferreira

Tipo

Artigo

Resumo

A histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.

Citação

Interciencia. Caracas: Interciencia, v. 19, n. 2, p. 75-78, 1994.