ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

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Data
1994-03-01
Autores
Segreto, Helena Regina Comodo [UNIFESP]
Segreto, Roberto Araujo [UNIFESP]
Thomaz, K.
Silva, MRR
Novo, Neil Ferreira [UNIFESP]
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A histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.
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Interciencia. Caracas: Interciencia, v. 19, n. 2, p. 75-78, 1994.
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