ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

Author Segreto, Helena Regina Comodo Autor UNIFESP Google Scholar
Segreto, Roberto Araujo Autor UNIFESP Google Scholar
Thomaz, K. Google Scholar
Silva, MRR Google Scholar
Novo, Neil Ferreira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.
Keywords IONIZING RADIATION
RADIOSENSITIZERS
ACUTE EFFECTS ON BONE MARROW
Language English
Date 1994-03-01
Published in Interciencia. Caracas: Interciencia, v. 19, n. 2, p. 75-78, 1994.
ISSN 0378-1844 (Sherpa/Romeo, impact factor)
Publisher Interciencia
Extent 75-78
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NC58900005
URI http://repositorio.unifesp.br/11600/43980

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