ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

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dc.contributor.authorSegreto, Helena Regina Comodo [UNIFESP]
dc.contributor.authorSegreto, Roberto Araujo [UNIFESP]
dc.contributor.authorThomaz, K.
dc.contributor.authorSilva, MRR
dc.contributor.authorNovo, Neil Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:44:08Z
dc.date.available2018-06-15T17:44:08Z
dc.date.issued1994-03-01
dc.description.abstractA histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT MED RADIOTERAPIA RADIOBIOL,RUA BOTUCATU 740,900 VILA CLEMENTINO,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT MED RADIOTERAPIA RADIOBIOL,RUA BOTUCATU 740,900 VILA CLEMENTINO,BR-04023 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent75-78
dc.identifier.citationInterciencia. Caracas: Interciencia, v. 19, n. 2, p. 75-78, 1994.
dc.identifier.issn0378-1844
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43980
dc.identifier.wosWOS:A1994NC58900005
dc.language.isoeng
dc.publisherInterciencia
dc.relation.ispartofInterciencia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIONIZING RADIATIONen
dc.subjectRADIOSENSITIZERSen
dc.subjectACUTE EFFECTS ON BONE MARROWen
dc.titleACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHODen
dc.typeinfo:eu-repo/semantics/article
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