Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
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2010-08-01
Autores
Longo, Beatriz 
Romariz, Simone
Blanco, Miriam Marcela
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P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
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Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.