Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

Author Longo, Beatriz Autor UNIFESP Google Scholar
Romariz, Simone Autor UNIFESP Google Scholar
Blanco, Miriam Marcela Autor UNIFESP Google Scholar
Vasconcelos, Juliana Fraga Google Scholar
Bahia, Luciana Google Scholar
Pereira Soares, Milena Botelho Google Scholar
Mello, Luiz E. Autor UNIFESP Google Scholar
Ribeiro-dos-Santos, Ricardo Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Sao Rafael
Abstract P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
Keywords Hippocampus
Chimeric mice
Microglia
Status epilepticus
GFP
Language English
Sponsor FAPESB
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FIOCRUZ
Date 2010-08-01
Published in Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1628-1632
Origin http://dx.doi.org/10.1111/j.1528-1167.2010.02570.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000280669600033
URI http://repositorio.unifesp.br/handle/11600/32744

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