Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

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dc.contributor.authorLongo, Beatriz [UNIFESP]
dc.contributor.authorRomariz, Simone [UNIFESP]
dc.contributor.authorBlanco, Miriam Marcela [UNIFESP]
dc.contributor.authorVasconcelos, Juliana Fraga
dc.contributor.authorBahia, Luciana
dc.contributor.authorPereira Soares, Milena Botelho
dc.contributor.authorMello, Luiz E. [UNIFESP]
dc.contributor.authorRibeiro-dos-Santos, Ricardo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Sao Rafael
dc.date.accessioned2016-01-24T14:05:14Z
dc.date.available2016-01-24T14:05:14Z
dc.date.issued2010-08-01
dc.description.abstractP>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Lab Neurofisiol, São Paulo, Brazil
dc.description.affiliationHosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Lab Neurofisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESB
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFIOCRUZ
dc.format.extent1628-1632
dc.identifierhttp://dx.doi.org/10.1111/j.1528-1167.2010.02570.x
dc.identifier.citationEpilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.
dc.identifier.doi10.1111/j.1528-1167.2010.02570.x
dc.identifier.issn0013-9580
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32744
dc.identifier.wosWOS:000280669600033
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofEpilepsia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectHippocampusen
dc.subjectChimeric miceen
dc.subjectMicrogliaen
dc.subjectStatus epilepticusen
dc.subjectGFPen
dc.titleDistribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in miceen
dc.typeinfo:eu-repo/semantics/article
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