Social play impairment following status epilepticus during early development

Santos Castelhano, Adelisandra Silva; Scorza, Fulvio Alexandre [UNIFESP]; Triguero Veloz Teixeira, Maria Cristina; Arida, Ricardo Mario [UNIFESP]; Cavalheiro, Esper Abrao [UNIFESP]; Cysneiros, Roberta Monterazzo

Social play impairment following status epilepticus during early development

Data

2010-10-01

Autores

Santos Castelhano, Adelisandra Silva

Scorza, Fulvio Alexandre

Triguero Veloz Teixeira, Maria Cristina

Arida, Ricardo Mario

Cavalheiro, Esper Abrao

Mostrar mais

Tipo

Artigo

Resumo

Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the intruder-resident paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.

Citação

Journal of Neural Transmission. Wien: Springer Wien, v. 117, n. 10, p. 1155-1160, 2010.