Social play impairment following status epilepticus during early development

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dc.contributor.authorSantos Castelhano, Adelisandra Silva
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorTriguero Veloz Teixeira, Maria Cristina
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorCysneiros, Roberta Monterazzo
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:30Z
dc.date.available2016-01-24T14:05:30Z
dc.date.issued2010-10-01
dc.description.abstractNeonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the intruder-resident paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.en
dc.description.affiliationUniv Presbiteriana Mackenzie, Neurobiol Lab, Programa Posgrad Disturbios Desenvolvimento, BR-01302907 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMACKPESQUISA
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1155-1160
dc.identifierhttp://dx.doi.org/10.1007/s00702-010-0460-1
dc.identifier.citationJournal of Neural Transmission. Wien: Springer Wien, v. 117, n. 10, p. 1155-1160, 2010.
dc.identifier.doi10.1007/s00702-010-0460-1
dc.identifier.issn0300-9564
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32943
dc.identifier.wosWOS:000284782100004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Neural Transmission
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectGenderen
dc.subjectNeonatalen
dc.subjectSocial interactionen
dc.subjectStatus epilepticusen
dc.titleSocial play impairment following status epilepticus during early developmenten
dc.typeinfo:eu-repo/semantics/article
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