Social play impairment following status epilepticus during early development

Social play impairment following status epilepticus during early development

Author Santos Castelhano, Adelisandra Silva Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Triguero Veloz Teixeira, Maria Cristina Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Cysneiros, Roberta Monterazzo Google Scholar
Institution Univ Presbiteriana Mackenzie
Universidade Federal de São Paulo (UNIFESP)
Abstract Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the intruder-resident paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
Keywords Gender
Neonatal
Social interaction
Status epilepticus
Language English
Sponsor MACKPESQUISA
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-10-01
Published in Journal of Neural Transmission. Wien: Springer Wien, v. 117, n. 10, p. 1155-1160, 2010.
ISSN 0300-9564 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1155-1160
Origin http://dx.doi.org/10.1007/s00702-010-0460-1
Access rights Closed access
Type Article
Web of Science ID WOS:000284782100004
URI http://repositorio.unifesp.br/handle/11600/32943

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