Avaliação da Barreira Hemato-Encefálica no transplante de medula óssea
Data
1997-12-01
Autores
Almeida, Sergio Monteiro de 
Mostrar mais
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The blood-brain barrier (BBB) contributes to the central nervous system (CNS) immunological isolation. BBB has never been studied in patients who developed chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplants (BMT), from HLA identical related donors. BB disruption was investigated through the cerebrospinal fluid (CSF) proteins, quantitative and graphically, in order to detect the incidence and possible pathophysiology of the CNS involvement in chronic GVHD. Thirty three CSF and matched serum samples from chronic myeloid leukemia patients were collected pre BMT, pos BMT and during chronic GVHD. There was no evidence of BBB disruption in any patient studied.
Descrição
Citação
Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 55, n. 4, p. 812-818, 1997.