Avaliação da Barreira Hemato-Encefálica no transplante de medula óssea

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dc.contributor.authorAlmeida, Sergio Monteiro de [UNIFESP]
dc.contributor.authorLivramento, Jose Antonio
dc.contributor.authorPasquini, Ricardo
dc.contributor.authorPalou, Viviana Boccardi
dc.contributor.authorOliveira, Aparecido Mendes de
dc.contributor.authorDoi, Elvira Missako
dc.contributor.authorOno, Margaret
dc.contributor.authorAso, Mirna Cigemi
dc.contributor.authorFerreira, Euripedes [UNIFESP]
dc.contributor.institutionUNIV FED PARANA
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T14:00:13Z
dc.date.available2018-06-15T14:00:13Z
dc.date.issued1997-12-01
dc.description.abstractThe blood-brain barrier (BBB) contributes to the central nervous system (CNS) immunological isolation. BBB has never been studied in patients who developed chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplants (BMT), from HLA identical related donors. BB disruption was investigated through the cerebrospinal fluid (CSF) proteins, quantitative and graphically, in order to detect the incidence and possible pathophysiology of the CNS involvement in chronic GVHD. Thirty three CSF and matched serum samples from chronic myeloid leukemia patients were collected pre BMT, pos BMT and during chronic GVHD. There was no evidence of BBB disruption in any patient studied.en
dc.description.affiliationUNIV FED PARANA,HOSP CLIN,DISCIPLINA NEUROL,BR-80060900 CURITIBA,PARANA,BRAZIL
dc.description.affiliationUNIV FED PARANA,HOSP CLIN,SERV TMO,BR-80060900 CURITIBA,PARANA,BRAZIL
dc.description.affiliationUNIFESP,EPM,DISCIPLINA IMUNOL,SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC MED,CTR INVEST NEUROL,BR-05508 SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIFESP,EPM,DISCIPLINA IMUNOL,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent812-818
dc.identifierhttp://dx.doi.org/10.1590/S0004-282X1997000500019
dc.identifier.citationArquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 55, n. 4, p. 812-818, 1997.
dc.identifier.doi10.1590/S0004-282X1997000500019
dc.identifier.fileS0004-282X1997000500019.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X1997000500019
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42730
dc.identifier.wosWOS:A1997YJ09100019
dc.language.isopor
dc.publisherAssoc Arquivos De Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgraft-versus-host diseaseen
dc.subjectblood-brain barrieren
dc.subjectauto immunityen
dc.subjectcerebrospinal fluiden
dc.subjectbone marrow transplantationen
dc.subjectalbuminen
dc.titleAvaliação da Barreira Hemato-Encefálica no transplante de medula ósseapt
dc.title.alternativeBlood-brain barrier evaluation in bone marrow transplantationen
dc.typeinfo:eu-repo/semantics/article
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