Avaliação da Barreira Hemato-Encefálica no transplante de medula óssea

Avaliação da Barreira Hemato-Encefálica no transplante de medula óssea

Alternative title Blood-brain barrier evaluation in bone marrow transplantation
Author Almeida, Sergio Monteiro de Autor UNIFESP Google Scholar
Livramento, Jose Antonio Google Scholar
Pasquini, Ricardo Google Scholar
Palou, Viviana Boccardi Google Scholar
Oliveira, Aparecido Mendes de Google Scholar
Doi, Elvira Missako Google Scholar
Ono, Margaret Google Scholar
Aso, Mirna Cigemi Google Scholar
Ferreira, Euripedes Autor UNIFESP Google Scholar
Institution UNIV FED PARANA
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The blood-brain barrier (BBB) contributes to the central nervous system (CNS) immunological isolation. BBB has never been studied in patients who developed chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplants (BMT), from HLA identical related donors. BB disruption was investigated through the cerebrospinal fluid (CSF) proteins, quantitative and graphically, in order to detect the incidence and possible pathophysiology of the CNS involvement in chronic GVHD. Thirty three CSF and matched serum samples from chronic myeloid leukemia patients were collected pre BMT, pos BMT and during chronic GVHD. There was no evidence of BBB disruption in any patient studied.
Keywords graft-versus-host disease
blood-brain barrier
auto immunity
cerebrospinal fluid
bone marrow transplantation
albumin
Language Portuguese
Date 1997-12-01
Published in Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 55, n. 4, p. 812-818, 1997.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos De Neuro- Psiquiatria
Extent 812-818
Origin http://dx.doi.org/10.1590/S0004-282X1997000500019
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1997YJ09100019
SciELO ID S0004-282X1997000500019 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42730

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