Acute action of aminophylline in patients with amyotrophic lateral sclerosis
Data
2007-05-01
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Artigo
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Resumo
Objective - This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). the study was a randomized, double-blind, crossover against placebo. Materials and methods - Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P-Imax/P-Emax) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. Results - MVV (P < 0.02) and HS of the right and left hands (P = 0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P-Imax (r = 0.80; P < 0.05); between MVV and P-Imax post-aminophylline, respectively (r = 0.77; P < 0.05). Serum aminophylline levels ranged from 5.3 to 10.5 mu g/mL (mean 7.30). Conclusion - the acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
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Citação
Acta Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 115, n. 5, p. 301-305, 2007.