Acute action of aminophylline in patients with amyotrophic lateral sclerosis

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dc.contributor.authorBerto, M. C.
dc.contributor.authorFilha, S. C.
dc.contributor.authorCamelier, A.
dc.contributor.authorRosa, F. W.
dc.contributor.authorOliveira, A. de Souza Bulle
dc.contributor.authorJardim, J. R.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:48:42Z
dc.date.available2016-01-24T13:48:42Z
dc.date.issued2007-05-01
dc.description.abstractObjective - This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). the study was a randomized, double-blind, crossover against placebo. Materials and methods - Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P-Imax/P-Emax) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. Results - MVV (P < 0.02) and HS of the right and left hands (P = 0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P-Imax (r = 0.80; P < 0.05); between MVV and P-Imax post-aminophylline, respectively (r = 0.77; P < 0.05). Serum aminophylline levels ranged from 5.3 to 10.5 mu g/mL (mean 7.30). Conclusion - the acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Resp, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Neurol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Resp, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Neurol, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent301-305
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0404.2007.00643.x
dc.identifier.citationActa Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 115, n. 5, p. 301-305, 2007.
dc.identifier.doi10.1111/j.1600-0404.2007.00643.x
dc.identifier.issn0001-6314
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29740
dc.identifier.wosWOS:000246198900002
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofActa Neurologica Scandinavica
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectamyotrophic lateral sclerosisen
dc.subjectmuscle weaknessen
dc.subjectenduranceen
dc.subjectaminophyllineen
dc.titleAcute action of aminophylline in patients with amyotrophic lateral sclerosisen
dc.typeinfo:eu-repo/semantics/article
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