Acute action of aminophylline in patients with amyotrophic lateral sclerosis

Acute action of aminophylline in patients with amyotrophic lateral sclerosis

Autor Berto, M. C. Google Scholar
Filha, S. C. Google Scholar
Camelier, A. Google Scholar
Rosa, F. W. Google Scholar
Oliveira, A. de Souza Bulle Google Scholar
Jardim, J. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective - This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). the study was a randomized, double-blind, crossover against placebo. Materials and methods - Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P-Imax/P-Emax) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. Results - MVV (P < 0.02) and HS of the right and left hands (P = 0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P-Imax (r = 0.80; P < 0.05); between MVV and P-Imax post-aminophylline, respectively (r = 0.77; P < 0.05). Serum aminophylline levels ranged from 5.3 to 10.5 mu g/mL (mean 7.30). Conclusion - the acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
Assunto amyotrophic lateral sclerosis
muscle weakness
Idioma Inglês
Data 2007-05-01
Publicado em Acta Neurologica Scandinavica. Oxford: Blackwell Publishing, v. 115, n. 5, p. 301-305, 2007.
ISSN 0001-6314 (Sherpa/Romeo, fator de impacto)
Editor Blackwell Publishing
Extensão 301-305
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000246198900002

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