PLASMID CODING for DRUG-RESISTANCE and INVASION of EPITHELIAL-CELLS in ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-
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1995-06-01
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Enteropathogenic Escherichia coli (EPEC) can adhere to, invade and multiply in human epithelial cells. To define the elements required for bacterial invasion, we isolated from an 0111:H- EPEC a 6.6 kb plasmid that is capable of conferring to an avirulent, non-adherent E. coli K12 strain (DK1) the capacity to invade epithelial cells. With this system a dissociation was possible between bacterial invasion and adherence to epithelial cells. Bacteria containing this plasmid synthesise a protein of 32 kDa (pi 4.93) which seemed to be required for cell invasion. the results provide a new basis for strategies to prevent EPEC infections.
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Microbial Pathogenesis. London: Academic Press (london) Ltd, v. 18, n. 6, p. 387-399, 1995.