PLASMID CODING for DRUG-RESISTANCE and INVASION of EPITHELIAL-CELLS in ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-

PLASMID CODING for DRUG-RESISTANCE and INVASION of EPITHELIAL-CELLS in ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-

Autor Scaletsky, ICA Google Scholar
Gatti, MSV Google Scholar
Dasilveira, J. F. Google Scholar
Deluca, IMS Google Scholar
Freymuller, E. Google Scholar
Travassos, L. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Resumo Enteropathogenic Escherichia coli (EPEC) can adhere to, invade and multiply in human epithelial cells. To define the elements required for bacterial invasion, we isolated from an 0111:H- EPEC a 6.6 kb plasmid that is capable of conferring to an avirulent, non-adherent E. coli K12 strain (DK1) the capacity to invade epithelial cells. With this system a dissociation was possible between bacterial invasion and adherence to epithelial cells. Bacteria containing this plasmid synthesise a protein of 32 kDa (pi 4.93) which seemed to be required for cell invasion. the results provide a new basis for strategies to prevent EPEC infections.
Palavra-chave EPEC
INVASION
PLASMID
Idioma Inglês
Data de publicação 1995-06-01
Publicado em Microbial Pathogenesis. London: Academic Press (london) Ltd, v. 18, n. 6, p. 387-399, 1995.
ISSN 0882-4010 (Sherpa/Romeo, fator de impacto)
Publicador Academic Press (london) Ltd
Extensão 387-399
Fonte http://dx.doi.org/10.1006/mpat.1995.0035
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RV31200002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25499

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