PLASMID CODING for DRUG-RESISTANCE and INVASION of EPITHELIAL-CELLS in ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-

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dc.contributor.authorScaletsky, ICA
dc.contributor.authorGatti, MSV
dc.contributor.authorDasilveira, J. F.
dc.contributor.authorDeluca, IMS
dc.contributor.authorFreymuller, E.
dc.contributor.authorTravassos, L. R.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T11:40:24Z
dc.date.available2016-01-24T11:40:24Z
dc.date.issued1995-06-01
dc.description.abstractEnteropathogenic Escherichia coli (EPEC) can adhere to, invade and multiply in human epithelial cells. To define the elements required for bacterial invasion, we isolated from an 0111:H- EPEC a 6.6 kb plasmid that is capable of conferring to an avirulent, non-adherent E. coli K12 strain (DK1) the capacity to invade epithelial cells. With this system a dissociation was possible between bacterial invasion and adherence to epithelial cells. Bacteria containing this plasmid synthesise a protein of 32 kDa (pi 4.93) which seemed to be required for cell invasion. the results provide a new basis for strategies to prevent EPEC infections.en
dc.description.affiliationESCOLA PAULISTA MED,CTR ELECTRON MICROSCOPY,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUNIV ESTADUAL CAMPINAS,DEPT MICROBIOL & IMMUNOL,BR-13081 CAMPINAS,BRAZIL
dc.description.affiliationUNIV ESTADUAL CAMPINAS,DEPT HISTOL,BR-13081 CAMPINAS,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,CTR ELECTRON MICROSCOPY,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent387-399
dc.identifierhttp://dx.doi.org/10.1006/mpat.1995.0035
dc.identifier.citationMicrobial Pathogenesis. London: Academic Press (london) Ltd, v. 18, n. 6, p. 387-399, 1995.
dc.identifier.doi10.1006/mpat.1995.0035
dc.identifier.issn0882-4010
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25499
dc.identifier.wosWOS:A1995RV31200002
dc.language.isoeng
dc.publisherAcademic Press (london) Ltd
dc.relation.ispartofMicrobial Pathogenesis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEPECen
dc.subjectINVASIONen
dc.subjectPLASMIDen
dc.titlePLASMID CODING for DRUG-RESISTANCE and INVASION of EPITHELIAL-CELLS in ENTEROPATHOGENIC ESCHERICHIA-COLI-0111-H-en
dc.typeinfo:eu-repo/semantics/article
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