Chronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assay
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2011-01-01
Autores
Nakamura, Mary Uchiyama 
Simoes, Ricardo Santos
Oliveira-Filho, Ricardo Martins
Fontes, Tereza Maria Pereira
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Purpose: To evaluate at term the effects of a highly active antiretroviral (HAAR) drug association administered during the entire period of rat pregnancy. Methods: Three groups (n = 10 each) of adult pregnant rats were treated with an oral solution of HAAR (Exp 1 = 10/5/20 mg/kg b.w.; Exp 2 = 30/15/60 mg/kg b.w.; Exp 3 = 90/45/180 mg/kg b.w.) from day 0 up to the 20th day of pregnancy. A fourth group served as a control. At term (20th day) the rats were killed under deep anesthesia and the number of implantations, resorptions, living fetuses, placentae and intrauterine deaths were recorded. Results: The highest HAAR doses caused lower maternal weight gain, lower litter weights, and lower placental weights compared to the control group. Conclusions: HAAR during the entire period of rat pregnancy can reduce maternal body weight gain and lower term placental weight.
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Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 38, n. 1, p. 28-32, 2011.