Chronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assay

Chronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assay

Author Wagner, A. Google Scholar
Nakamura, Mary Uchiyama Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Autor UNIFESP Google Scholar
Oliveira-Filho, Ricardo Martins Autor UNIFESP Google Scholar
Fontes, Tereza Maria Pereira Autor UNIFESP Google Scholar
Carvalho, Luisa Patricia Fogarolli de Autor UNIFESP Google Scholar
Espiridião, Silvia Autor UNIFESP Google Scholar
Kulay Júnior, Luiz Autor UNIFESP Google Scholar
Institution Univ Jose do Rosario Vellano
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Purpose: To evaluate at term the effects of a highly active antiretroviral (HAAR) drug association administered during the entire period of rat pregnancy. Methods: Three groups (n = 10 each) of adult pregnant rats were treated with an oral solution of HAAR (Exp 1 = 10/5/20 mg/kg b.w.; Exp 2 = 30/15/60 mg/kg b.w.; Exp 3 = 90/45/180 mg/kg b.w.) from day 0 up to the 20th day of pregnancy. A fourth group served as a control. At term (20th day) the rats were killed under deep anesthesia and the number of implantations, resorptions, living fetuses, placentae and intrauterine deaths were recorded. Results: The highest HAAR doses caused lower maternal weight gain, lower litter weights, and lower placental weights compared to the control group. Conclusions: HAAR during the entire period of rat pregnancy can reduce maternal body weight gain and lower term placental weight.
Keywords Rat
Pregnancy
Zidovudine
Lamivudine
Ritonavir
Language English
Date 2011-01-01
Published in Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 38, n. 1, p. 28-32, 2011.
ISSN 0390-6663 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 28-32
Access rights Closed access
Type Article
Web of Science ID WOS:000288055100007
URI http://repositorio.unifesp.br/11600/43291

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