Chronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assay

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dc.contributor.authorWagner, A.
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins [UNIFESP]
dc.contributor.authorFontes, Tereza Maria Pereira [UNIFESP]
dc.contributor.authorCarvalho, Luisa Patricia Fogarolli de [UNIFESP]
dc.contributor.authorEspiridião, Silvia [UNIFESP]
dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.contributor.institutionUniv Jose do Rosario Vellano
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T16:52:38Z
dc.date.available2018-06-15T16:52:38Z
dc.date.issued2011-01-01
dc.description.abstractPurpose: To evaluate at term the effects of a highly active antiretroviral (HAAR) drug association administered during the entire period of rat pregnancy. Methods: Three groups (n = 10 each) of adult pregnant rats were treated with an oral solution of HAAR (Exp 1 = 10/5/20 mg/kg b.w.; Exp 2 = 30/15/60 mg/kg b.w.; Exp 3 = 90/45/180 mg/kg b.w.) from day 0 up to the 20th day of pregnancy. A fourth group served as a control. At term (20th day) the rats were killed under deep anesthesia and the number of implantations, resorptions, living fetuses, placentae and intrauterine deaths were recorded. Results: The highest HAAR doses caused lower maternal weight gain, lower litter weights, and lower placental weights compared to the control group. Conclusions: HAAR during the entire period of rat pregnancy can reduce maternal body weight gain and lower term placental weight.en
dc.description.affiliationUniv Jose do Rosario Vellano, Dept Obstet & Gynecol, Alfenas, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent28-32
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 38, n. 1, p. 28-32, 2011.
dc.identifier.issn0390-6663
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43291
dc.identifier.wosWOS:000288055100007
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectRaten
dc.subjectPregnancyen
dc.subjectZidovudineen
dc.subjectLamivudineen
dc.subjectRitonaviren
dc.titleChronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assayen
dc.typeinfo:eu-repo/semantics/article
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