Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Rodrigues, Marcelo Cairrão Araujo; Ribeiro, Alessandra Mussi; Pizzo, Andrea Baldocchi; Fontana, Andreia Cristina Karklin; Beleboni, Renê de Oliveira; Coutinho-Netto, Joaquim; Miranda, Antonio de [UNIFESP]; Santos, Wagner Ferreira dos

Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Data

2002-09-01

Autores

Rodrigues, Marcelo Cairrão Araujo

Ribeiro, Alessandra Mussi

Pizzo, Andrea Baldocchi

Fontana, Andreia Cristina Karklin

Beleboni, Renê de Oliveira

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Tipo

Artigo

Resumo

In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.

Citação

Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.