Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

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dc.contributor.authorRodrigues, Marcelo Cairrão Araujo
dc.contributor.authorRibeiro, Alessandra Mussi
dc.contributor.authorPizzo, Andrea Baldocchi
dc.contributor.authorFontana, Andreia Cristina Karklin
dc.contributor.authorBeleboni, Renê de Oliveira
dc.contributor.authorCoutinho-Netto, Joaquim
dc.contributor.authorMiranda, Antonio de [UNIFESP]
dc.contributor.authorSantos, Wagner Ferreira dos
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:30Z
dc.date.available2016-01-24T12:33:30Z
dc.date.issued2002-09-01
dc.description.abstractIn this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.en
dc.description.affiliationUniv São Paulo, Lab Neurobiol & Peconhas, Dept Biol, Fac Filosofia,Ciencias & Letras Ribeirao Preto, BR-14049901 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Lab Neuroquim, Dept Bioquim, BR-14049901 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent472-477
dc.identifierhttps://dx.doi.org/10.1076/phbi.40.6.472.8436
dc.identifier.citationPharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
dc.identifier.doi10.1076/phbi.40.6.472.8436
dc.identifier.issn1388-0209
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26969
dc.identifier.wosWOS:000179940300014
dc.language.isoeng
dc.publisherSwets Zeitlinger Publishers
dc.relation.ispartofPharmaceutical Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAnticonvulsanten
dc.subjectBicucullineen
dc.subjectGABAen
dc.subjectGABA uptakeen
dc.subjectParawixia bistriataen
dc.subjectPentilenetetrazoleen
dc.subjectPicrotoxinen
dc.subjectScaptocosa raptoriaen
dc.subjectSpider venomen
dc.subjectRat synaptosomesen
dc.titleAnticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoriaen
dc.typeinfo:eu-repo/semantics/article
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