Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Date
2002-09-01Author
Rodrigues, Marcelo Cairrão Araujo
Ribeiro, Alessandra Mussi
Pizzo, Andrea Baldocchi
Fontana, Andreia Cristina Karklin
Beleboni, Renê de Oliveira
Coutinho-Netto, Joaquim
Miranda, Antonio de [UNIFESP]
Santos, Wagner Ferreira dos
Type
ArtigoISSN
1388-0209Is part of
Pharmaceutical BiologyDOI
10.1076/phbi.40.6.472.8436Metadata
Show full item recordAbstract
In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
Citation
Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.Keywords
AnticonvulsantBicuculline
GABA
GABA uptake
Parawixia bistriata
Pentilenetetrazole
Picrotoxin
Scaptocosa raptoria
Spider venom
Rat synaptosomes
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