Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Author	Cairrao, MAR Ribeiro, A. M. Pizzo, A. B. Fontana, ACK Beleboni, R. O. Coutinho-Netto, J. Miranda, A. Santos, W. F.
Institution	Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP)
Abstract	In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
Keywords	anticonvulsant bicuculline GABA GABA uptake Parawixia bistriata pentilenetetrazole picrotoxin Scaptocosa raptoria spider venom rat synaptosomes
Language	English
Date	2002-09-01
Published in	Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
ISSN	1388-0209 (Sherpa/Romeo, impact factor)
Publisher	Swets Zeitlinger Publishers
Extent	472-477
Origin	http://dx.doi.org/10.1076/phbi.40.6.472.8436
Access rights	Closed access
Type	Article
Web of Science ID	WOS:000179940300014
URI	http://repositorio.unifesp.br/handle/11600/26969

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