• RI - Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
    • português (Brasil)
    • English
    • español
  • Sobre
    • RI Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
  • English 
    • português (Brasil)
    • English
    • español
    • português (Brasil)
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • Escola Paulista de Medicina (EPM)
  • EPM - Artigos
  • View Item
  •   DSpace Home
  • Escola Paulista de Medicina (EPM)
  • EPM - Artigos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Thumbnail
Date
2002-09-01
Author
Rodrigues, Marcelo Cairrão Araujo
Ribeiro, Alessandra Mussi
Pizzo, Andrea Baldocchi
Fontana, Andreia Cristina Karklin
Beleboni, Renê de Oliveira
Coutinho-Netto, Joaquim
Miranda, Antonio de [UNIFESP]
Santos, Wagner Ferreira dos
Type
Artigo
ISSN
1388-0209
Is part of
Pharmaceutical Biology
DOI
10.1076/phbi.40.6.472.8436
Metadata
Show full item record
Abstract
In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
Citation
Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
Keywords
Anticonvulsant
Bicuculline
GABA
GABA uptake
Parawixia bistriata
Pentilenetetrazole
Picrotoxin
Scaptocosa raptoria
Spider venom
Rat synaptosomes
URI
https://repositorio.unifesp.br/handle/11600/26969
Collections
  • EPM - Artigos [17709]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy Submit DateThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Submit Date

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV