Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP
Data
2001-01-22
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Artigo
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Resumo
NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. the turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. in addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier B.V. All rights reserved.
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Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-Elsevier B.V., v. 11, n. 2, p. 141-144, 2001.