Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Author Harrison, J. A. Google Scholar
Kartha, KPR Google Scholar
Turnbull, W. B. Google Scholar
Scheuerl, S. L. Google Scholar
Naismith, J. H. Google Scholar
Schenkman, S. Google Scholar
Field, R. A. Google Scholar
Institution Univ St Andrews
Universidade Federal de São Paulo (UNIFESP)
Abstract NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. the turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. in addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier B.V. All rights reserved.
Language English
Date 2001-01-22
Published in Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-Elsevier B.V., v. 11, n. 2, p. 141-144, 2001.
ISSN 0960-894X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 141-144
Origin http://dx.doi.org/10.1016/S0960-894X(00)00611-9
Access rights Closed access
Type Article
Web of Science ID WOS:000166648100013
URI http://repositorio.unifesp.br/handle/11600/26476

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