Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease
Data
2018
Autores
Adegoke, Samuel Ademola 
Braga, Josefina Aparecida Pellegrini
Figueiredo, Maria Stella
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
Descrição
Citação
Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.