Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

Author Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Braga, Josefina Aparecida Pellegrini Autor UNIFESP Google Scholar
Adekile, Adekunle D. Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Abstract Objective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
Keywords fat percentage
growth
hydroxyurea
25-hydroxyvitamin D
nutritional status
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Brazil National Council for Scientific and Technological Development, CNPq
Brazil National Council for Research (CNPq)
Sickle Cell Support Society of Nigeria (SCSSN)
CNPq-African Countries Collaborative Postgraduate Research Training in Sickle Cell Disease
Grant number CNPq: 159581/2014-1
Date 2018
Published in Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.
ISSN 1077-4114 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent E243-E247
Origin http://dx.doi.org/10.1097/MPH.0000000000001002
Access rights Closed access
Type Article
Web of Science ID WOS:000431106500011
URI https://repositorio.unifesp.br/handle/11600/55573

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