Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

Date
2018Author
Adegoke, Samuel Ademola [UNIFESP]
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Adekile, Adekunle D.
Figueiredo, Maria Stella [UNIFESP]
Type
ArtigoISSN
1077-4114Is part of
Journal Of Pediatric Hematology OncologyDOI
10.1097/MPH.0000000000001002Metadata
Show full item recordAbstract
Objective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
Citation
Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.Sponsorship
Brazil National Council for Scientific and Technological Development, CNPqBrazil National Council for Research (CNPq)
Sickle Cell Support Society of Nigeria (SCSSN)
CNPq-African Countries Collaborative Postgraduate Research Training in Sickle Cell Disease
Collections
- EPM - Artigos [17701]