Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

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dc.citation.issue4
dc.citation.volumev. 40
dc.contributor.authorAdegoke, Samuel Ademola [UNIFESP]
dc.contributor.authorBraga, Josefina Aparecida Pellegrini [UNIFESP]
dc.contributor.authorAdekile, Adekunle D.
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-20T16:30:53Z
dc.date.available2020-07-20T16:30:53Z
dc.date.issued2018
dc.description.abstractObjective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.en
dc.description.affiliationUniv Fed Sao Paulo, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationObafemi Awolowo Univ, Dept Pediat & Child Hlth, PMB 013, Ife, Nigeria
dc.description.affiliationKuwait Univ, Dept Paediat, Fac Med, Kuwait, Kuwait
dc.description.affiliationUnifespUniv Fed Sao Paulo, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazil National Council for Scientific and Technological Development, CNPq
dc.description.sponsorshipBrazil National Council for Research (CNPq)
dc.description.sponsorshipSickle Cell Support Society of Nigeria (SCSSN)
dc.description.sponsorshipCNPq-African Countries Collaborative Postgraduate Research Training in Sickle Cell Disease
dc.description.sponsorshipIDCNPq: 159581/2014-1
dc.format.extentE243-E247
dc.identifierhttp://dx.doi.org/10.1097/MPH.0000000000001002
dc.identifier.citationJournal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.
dc.identifier.doi10.1097/MPH.0000000000001002
dc.identifier.issn1077-4114
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55573
dc.identifier.wosWOS:000431106500011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Pediatric Hematology Oncology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectfat percentageen
dc.subjectgrowthen
dc.subjecthydroxyureaen
dc.subject25-hydroxyvitamin Den
dc.subjectnutritional statusen
dc.titleImpact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Diseaseen
dc.typeinfo:eu-repo/semantics/article
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