Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

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dc.citation.issue4
dc.citation.volumev. 40
dc.contributor.authorAdegoke, Samuel Ademola [UNIFESP]
dc.contributor.authorBraga, Josefina Aparecida Pellegrini [UNIFESP]
dc.contributor.authorAdekile, Adekunle D.
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-20T16:30:53Z
dc.date.available2020-07-20T16:30:53Z
dc.date.issued2018
dc.description.abstractObjective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.en
dc.description.affiliationUniv Fed Sao Paulo, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationObafemi Awolowo Univ, Dept Pediat & Child Hlth, PMB 013, Ife, Nigeria
dc.description.affiliationKuwait Univ, Dept Paediat, Fac Med, Kuwait, Kuwait
dc.description.affiliationUnifespUniv Fed Sao Paulo, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-20T16:30:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazil National Council for Scientific and Technological Development, CNPq
dc.description.sponsorshipBrazil National Council for Research (CNPq)
dc.description.sponsorshipSickle Cell Support Society of Nigeria (SCSSN)
dc.description.sponsorshipCNPq-African Countries Collaborative Postgraduate Research Training in Sickle Cell Disease
dc.description.sponsorshipIDCNPq: 159581/2014-1
dc.format.extentE243-E247
dc.identifierhttp://dx.doi.org/10.1097/MPH.0000000000001002
dc.identifier.citationJournal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 4, p. E243-E247, 2018.
dc.identifier.doi10.1097/MPH.0000000000001002
dc.identifier.issn1077-4114
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55573
dc.identifier.wosWOS:000431106500011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Pediatric Hematology Oncology
dc.rightsAcesso restrito
dc.subjectfat percentageen
dc.subjectgrowthen
dc.subjecthydroxyureaen
dc.subject25-hydroxyvitamin Den
dc.subjectnutritional statusen
dc.titleImpact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Diseaseen
dc.typeArtigo
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