Avaliação da Concentração de Vitamina D em Pacientes Portadores de COVID-19
Data
2021-04-26
Autores
Yu Tsun, Lai [UNIFESP]
Orientadores
Pereira, Edimar Cristiano [UNIFESP]
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Vitamina D é o nome dado a um grupo de substâncias esteroidais lipossolúveis de importância fisiológica para o nosso organismo, principalmente no metabolismo ósseo. Acredita-se que a forma ativa da vitamina D apresenta efeitos imunomoduladores sobre as células do sistema imunológico, sobretudo linfócitos T, bem como na produção e na ação de diversas citocinas e expressão de peptídeos antimicrobianos potentes em células epiteliais que revestem o trato respiratório, desempenhando um papel importante na proteção do pulmão contra infecções. Dessa forma, pode ser observada a importância dessa vitamina nas complicações respiratórias agudas desencadeadas pela infecção da COVID-19. A COVID-19 é atualmente considerada uma pandemia global pela Organização Mundial de Saúde, causada pelo novo coronavírus SARS-CoV-2, uma preocupação para a saúde pública global. Baseado nesse cenário, este estudo tem como objetivo avaliar a concentração sérica da Vitamina D em 300 pacientes com suspeita de infecção por COVID-19, atendidos em UBSs e no Complexo Hospitalar do município de São Bernardo do Campo. Posteriormente, os prontuários desses pacientes foram consultados para verificar o desfecho dessa suspeita de infecção por COVID-19 e classificados em pacientes não infectados (PCR e/ou sorologia negativa para COVID-19) e infectados (PCR e/ou sorologia positiva para COVID-19). Os pacientes PCR e/ou soropositivos para COVID- 19 foram subdivididos quanto à evolução do caso clínico: LEVE (sem necessidade de internação), MODERADO (internação sem necessidade de UTI), GRAVE (UTI) e ÓBITO. Foram incluídos 294 pacientes, sendo 195 (66%) positivo para COVID-19 e 99 (34%) negativo para COVID-19. Entre os pacientes do grupo positivo, 163 pacientes pertencem ao grupo LEVE (84%); 22 pacientes pertencem ao grupo MODERADO (11%); 8 pacientes pertencem ao grupo GRAVE (4%) e 2 pacientes pertencem ao grupo ÓBITO (1%). Para os pacientes dessa pesquisa não se observou associação ao fator protetor da vitamina D contra infecção de COVID-19 e também não foi verificado o seu papel no controle de estadiamento do desenvolvimento da doença.
Vitamin D is the name given to a group of liposoluble steroidal substances with physiological importance to our body, especially in bone metabolism. It is believed that the active form of vitamin D presents immunomodulatory effects on the cells of the immune system, especially T lymphocytes, as well as in the production and action of various cytokines and the expression of powerful antimicrobial peptides in epithelial cells that coat the respiratory tract, playing an important role in protecting the lung against infections. Thus, the importance of this vitamin in acute respiratory complications triggered by COVID-19 can be observed. COVID-19 is a global pandemic declared by the World Health Organization and caused by the new SARS- CoV-2 coronavirus, a current concern for global public health. Based on this scene, this study aims to evaluate the serum concentration of Vitamin D in 300 patients with suspected infection of COVID-19 treated at Basic Unit of Health in São Bernardo do Campo and Hospital Complex in the city of São Bernardo do Campos. Afterwards, the records of these patients will be consulted to verify the outcome of this suspected infection by COVID-19 and classify them in non-infected patients (PCR and/or serology negative for COVID-19) and infected patients (PCR and/or serology positive for COVID-19). The PCR and/or seropositive serology for COVID-19 patients were subdivided according to the evolution of the clinical case: MILD (no need for hospitalization), MODERATE (hospitalization without need for ICU), SEVERE (ICU) and DEATH. With this information, it is intended to verify if the vitamin D concentration is an indicative factor of severity in the clinical evolution of the patient infected by COVID-19. So far 294 patients have been included in the study, being 195 (66%) positive for COVID-19 and 99 (34%) negative for COVID-19. A total of 294 patients participated at the end, with 195 (66%) positive for COVID-19 and 99 (34%) negative for COVID-19. Within the positive group, 163 patients belong to the Mild group (84%); 22 patients belong to the MODERATE group (11%); 8 patients belong to the SERIOUS group (4%); 2 patients belong to the DEAD group (1%). For the patients in this research, the protective role of vitamin D against COVID-19 infection was not observed and also its role in controlling the disease development was not verified.
Vitamin D is the name given to a group of liposoluble steroidal substances with physiological importance to our body, especially in bone metabolism. It is believed that the active form of vitamin D presents immunomodulatory effects on the cells of the immune system, especially T lymphocytes, as well as in the production and action of various cytokines and the expression of powerful antimicrobial peptides in epithelial cells that coat the respiratory tract, playing an important role in protecting the lung against infections. Thus, the importance of this vitamin in acute respiratory complications triggered by COVID-19 can be observed. COVID-19 is a global pandemic declared by the World Health Organization and caused by the new SARS- CoV-2 coronavirus, a current concern for global public health. Based on this scene, this study aims to evaluate the serum concentration of Vitamin D in 300 patients with suspected infection of COVID-19 treated at Basic Unit of Health in São Bernardo do Campo and Hospital Complex in the city of São Bernardo do Campos. Afterwards, the records of these patients will be consulted to verify the outcome of this suspected infection by COVID-19 and classify them in non-infected patients (PCR and/or serology negative for COVID-19) and infected patients (PCR and/or serology positive for COVID-19). The PCR and/or seropositive serology for COVID-19 patients were subdivided according to the evolution of the clinical case: MILD (no need for hospitalization), MODERATE (hospitalization without need for ICU), SEVERE (ICU) and DEATH. With this information, it is intended to verify if the vitamin D concentration is an indicative factor of severity in the clinical evolution of the patient infected by COVID-19. So far 294 patients have been included in the study, being 195 (66%) positive for COVID-19 and 99 (34%) negative for COVID-19. A total of 294 patients participated at the end, with 195 (66%) positive for COVID-19 and 99 (34%) negative for COVID-19. Within the positive group, 163 patients belong to the Mild group (84%); 22 patients belong to the MODERATE group (11%); 8 patients belong to the SERIOUS group (4%); 2 patients belong to the DEAD group (1%). For the patients in this research, the protective role of vitamin D against COVID-19 infection was not observed and also its role in controlling the disease development was not verified.