Avaliação dos efeitos da orfenadrina no desenvolvimento embriolarval de Echinometra lucunter
Data
2021-08-13
Autores
Silva, Victor Simões da 
Orientadores
Cesar, Augusto
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Os efluentes constantemente lançados no mar não recebem um tratamento apropriado para que se retire completamente os componentes químicos dos FPCPs, fazendo com que esses resíduos com potencial farmacológico ativo ainda possam causar implicações na vida marinha. Ao serem lançados no ambiente, esses compostos tendem a interagir e acumular no sedimento, que passam a funcionar como repositório e fonte de contaminação para organismos bentônicos e organismos pelágicos. Essa interação com o sedimento transforma esses contaminantes através de processos químicos e cria subprodutos que são mais reativos, podendo aumentar sua biodisponibilidade. A orfenadrina é o composto ativo de diversos fármacos amplamente utilizados no mundo. No Brasil, parte destes medicamentos são isentos de prescrição médica e são utilizados em níveis elevados pela população. Pela falta de êxito dos tratamentos tradicionais para a completa remoção desses compostos nos efluentes, esses fármacos podem ser encontrados no mar, próximo a regiões urbanas e há estudos que demonstram maior concentração da orfenadrina no ambiente na matriz água em comparação a matriz sedimento. Diante disso, o estudo avaliou os efeitos da orfenadrina no desenvolvimento embriolarval dos ouriços no sedimento. Foi possível observar efeito direto do fármaco no desenvolvimento e embora a concentração utilizada pelo estudo tenha sido menor que a ambiental, o estudo sugere mais pesquisas com diferentes tempos de exposição e organismos diferentes.
The effluents constantly released into the sea do not receive an appropriate treatment to completely remove the chemical components from the FPCPs, meaning that these residues with active pharmacological potential can still have implications for marine life. When released into the environment, these compounds tend to interact and accumulate in the sediment, which start to function as a repository and source of contamination for benthic and pelagic organisms. This interaction with the sediment transforms these contaminants through chemical processes and creates by-products that are more reactive, which can increase their bioavailability. Orphenadrine is the active compound of several drugs widely used in the world. In Brazil, some of these drugs are free of medical prescription and are used at high levels by the population. Due to the lack of success of traditional treatments for the complete removal of these compounds in effluents, these drugs can be found in the sea, close to urban areas and there are studies that demonstrate a higher concentration of orphenadrine in the environment in the water matrix compared to the sediment matrix. Therefore, the study evaluated the effects of orphenadrine on the embryolarval development of hedgehogs in the sediment. It was possible to observe the drug's direct effect on development and although the concentration used in the study was lower than the environmental one, the study suggests more research with different exposure times and different organisms.
The effluents constantly released into the sea do not receive an appropriate treatment to completely remove the chemical components from the FPCPs, meaning that these residues with active pharmacological potential can still have implications for marine life. When released into the environment, these compounds tend to interact and accumulate in the sediment, which start to function as a repository and source of contamination for benthic and pelagic organisms. This interaction with the sediment transforms these contaminants through chemical processes and creates by-products that are more reactive, which can increase their bioavailability. Orphenadrine is the active compound of several drugs widely used in the world. In Brazil, some of these drugs are free of medical prescription and are used at high levels by the population. Due to the lack of success of traditional treatments for the complete removal of these compounds in effluents, these drugs can be found in the sea, close to urban areas and there are studies that demonstrate a higher concentration of orphenadrine in the environment in the water matrix compared to the sediment matrix. Therefore, the study evaluated the effects of orphenadrine on the embryolarval development of hedgehogs in the sediment. It was possible to observe the drug's direct effect on development and although the concentration used in the study was lower than the environmental one, the study suggests more research with different exposure times and different organisms.
Descrição
Citação
SILVA, Victor Simões da. Avaliação dos efeitos da orfenadrina no desenvolvimento embriolarval de Echinometra lucunter. 2021. 19 f. Trabalho de conclusão de curso (Graduação em Bacharelado Interdisciplinar em Ciência e Tecnologia do Mar) - Instituto do Mar, Universidade Federal de São Paulo, Santos, 2021.