Efeitos do quiabo e/ou treinamento físico na estrutura e função renal de animais com síndrome metabólica
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Data
2020-04-15
Autores
Silva, Monique Marques da [UNIFESP]
Orientadores
Medeiros, Alessandra [UNIFESP]
Tipo
Dissertação de mestrado
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Resumo
Dentre as complicações da Síndrome Metabólica (SM) pode-se citar a doença renal e grande parte dos pacientes dialíticos tem diagnóstico de SM. O benefício do exercício físico para o tratamento da SM já está bem definido na literatura, porém, os benefícios antidiabético e anti-hiperlipidêmico do quiabo foram descobertos recentemente. O objetivo do presente estudo foi avaliar os efeitos da suplementação do Q e/ou TF na função e histologia renal; no valor sérico de ureia e creatinina; na inflamação (IL-6, IL-10, TNF-α); na expressão proteica do NF-kB e no estresse oxidativo. Observamos que os animais com SM maior deposição de fibrose acompanhado de pior estágio de lesão renal, além do aumento do peso dos rins. Todas as intervenções foram benéficas na redução da fibrose, porém, somente o TFQ foi capaz de melhorar o grau do comprometimento tecidual renal. O TF apresentou melhor estado anti- inflamatório e na atividade da catalase o TFQ foi mais benéfico. A função renal não estava alterada nesses animais. Em conclusão, o TF se mostrou benéfico na ação anti-inflamatória, o TFQ demonstrou melhor resultado na atividade da enzima antioxidante catalase e todas as intervenções preveniram maior deposição de fibrose renal. Sendo assim, o TF e TFQ podem ser benéficos para evitar a progressão da doença renal e quando ainda não há alterações renais instaladas.
Among the complications of Metabolic Syndrome (MetS), kidney disease can be cited and most dialysis patients are diagnosed with MetS. The benefit of physical exercise for the treatment of MetS is well defined in the literature, however, the antidiabetic and anti-hyperlipidemic benefits of okra have been recently discovered. The aim of the present study was to evaluate the effects of Q and / or TF supplementation on renal function and histology; the serum value of urea and creatinine; in inflammation (IL-6, IL-10, TNF-α); protein expression of NF-kB and oxidative stress. We observed that animals with MetS increased deposition of fibrosis accompanied by a worse stage of kidney injury, in addition to increased kidney weight. All interventions were beneficial in reducing fibrosis, however, only the TFQ was able to improve the degree of renal tissue impairment. TF showed a better anti-inflammatory state and in catalase activity, TFQ was more beneficial. Renal function was not altered in these animals. In conclusion, TF was shown to be beneficial in anti-inflammatory action, TFQ demonstrated better results in the activity of the antioxidant enzyme catalase and all interventions prevented greater deposition of renal fibrosis. Thus, TF and TFQ can be beneficial to prevent the progression of kidney disease and when there are still no renal changes installed.
Among the complications of Metabolic Syndrome (MetS), kidney disease can be cited and most dialysis patients are diagnosed with MetS. The benefit of physical exercise for the treatment of MetS is well defined in the literature, however, the antidiabetic and anti-hyperlipidemic benefits of okra have been recently discovered. The aim of the present study was to evaluate the effects of Q and / or TF supplementation on renal function and histology; the serum value of urea and creatinine; in inflammation (IL-6, IL-10, TNF-α); protein expression of NF-kB and oxidative stress. We observed that animals with MetS increased deposition of fibrosis accompanied by a worse stage of kidney injury, in addition to increased kidney weight. All interventions were beneficial in reducing fibrosis, however, only the TFQ was able to improve the degree of renal tissue impairment. TF showed a better anti-inflammatory state and in catalase activity, TFQ was more beneficial. Renal function was not altered in these animals. In conclusion, TF was shown to be beneficial in anti-inflammatory action, TFQ demonstrated better results in the activity of the antioxidant enzyme catalase and all interventions prevented greater deposition of renal fibrosis. Thus, TF and TFQ can be beneficial to prevent the progression of kidney disease and when there are still no renal changes installed.
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Citação
SILVA, Monique Marques da. Efeitos do quiabo e/ou treinamento físico na estrutura e função renal de animais com síndrome metabólica. 2020. 87 f. Dissertação (Mestrado Interdisciplinar em Ciências da Saúde) - Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Santos, 2020.