Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma

Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma

Author Ponci, Vitor Autor UNIFESP Google Scholar
Silva, Rafael Cossi da Autor UNIFESP Google Scholar
Santana, Fernanda Paula Roncon Autor UNIFESP Google Scholar
Grecco, Simone dos Santos Autor UNIFESP Google Scholar
Fortunato, Célia Regina Martinez Google Scholar
Oliveira, Maria Aparecida de Google Scholar
Tavares-de-Lima, Wothan Google Scholar
Olivo, Clarice Rosa Google Scholar
Tibério, Iolanda de Fátima Lopes Calvo Google Scholar
Gomes, Kaio de Souza Google Scholar
Prado, Carla Máximo Autor UNIFESP Google Scholar
Lago, Joao Henrique Ghilardi Google Scholar
Abstract In the present work, the anti-inflammatory and antiasthmatic potential of biseugenol, isolated as the main component from n-hexane extract from leaves of Nectandra leucantha and chemically prepared using oxidative coupling from eugenol, was evaluated in an experimental model of mixed-granulocytic asthma. Initially, in silico studies of biseugenol showed good predictions for drug-likeness, with adherence to Lipinski’s rules of five (RO5), good Absorption, Distribution, Metabolism and Excretion (ADME) properties and no alerts for Pan-Assay Interference Compounds (PAINS), indicating adequate adherence to perform in vivo assays. Biseugenol (20 mg·kg−1) was thus administered intraperitoneally (four days of treatment) and resulted in a significant reduction in both eosinophils and neutrophils of bronchoalveolar lavage fluid in ovalbumin-sensitized mice with no statistical difference from dexamethasone (5 mg·kg−1). As for lung function parameters, biseugenol (20 mg·kg−1) significantly reduced airway and tissue damping in comparison to ovalbumin group, with similar efficacy to positive control dexamethasone. Airway hyperresponsiveness to intravenous methacholine was reduced with biseugenol but was inferior to dexamethasone in higher doses. In conclusion, biseugenol displayed antiasthmatic effects, as observed through the reduction of inflammation and airway hyperresponsiveness, with similar effects to dexamethasone, on mixed-granulocytic ovalbumin-sensitized mice
Keywords Biseugenol
Mixed-granulocytic asthma
Airway responsiveness
Airway inflammation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2018/06088-0
Date 2020-11-18
Published in Ponci V, Silva RC, Santana FPR, Grecco SS, Fortunato CRM, Oliveira MA, Tavares-de-Lima W, Olivo CR, Tibério IdFLC, Gomes KS, Prado CM, Lago JHG. Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma. Molecules. 2020; 25(22):5384. https://doi.org/10.3390/molecules25225384
ISSN 1420-3049 (Sherpa/Romeo)
Publisher Prof. Dr. R. Daniel Little
Extent 1-13
Origin https://doi.org/10.3390/molecules25225384
Access rights Open access Open Access
Type Article
URI https://repositorio.unifesp.br/handle/11600/60803

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