Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma

Página do item simplificado
dc.citation.issue5384pt_BR
dc.citation.volume25pt_BR
dc.contributor.authorPonci, Vitor [UNIFESP]
dc.contributor.authorSilva, Rafael Cossi da [UNIFESP]
dc.contributor.authorSantana, Fernanda Paula Roncon [UNIFESP]
dc.contributor.authorGrecco, Simone dos Santos [UNIFESP]
dc.contributor.authorFortunato, Célia Regina Martinez
dc.contributor.authorOliveira, Maria Aparecida de
dc.contributor.authorTavares-de-Lima, Wothan
dc.contributor.authorOlivo, Clarice Rosa
dc.contributor.authorTibério, Iolanda de Fátima Lopes Calvo
dc.contributor.authorGomes, Kaio de Souza
dc.contributor.authorPrado, Carla Máximo [UNIFESP]
dc.contributor.authorLago, Joao Henrique Ghilardi
dc.contributor.authorLatteshttp://lattes.cnpq.br/1740478426977844pt_BR
dc.date.accessioned2021-04-01T19:35:22Z
dc.date.available2021-04-01T19:35:22Z
dc.date.issued2020-11-18
dc.description.abstractIn the present work, the anti-inflammatory and antiasthmatic potential of biseugenol, isolated as the main component from n-hexane extract from leaves of Nectandra leucantha and chemically prepared using oxidative coupling from eugenol, was evaluated in an experimental model of mixed-granulocytic asthma. Initially, in silico studies of biseugenol showed good predictions for drug-likeness, with adherence to Lipinski’s rules of five (RO5), good Absorption, Distribution, Metabolism and Excretion (ADME) properties and no alerts for Pan-Assay Interference Compounds (PAINS), indicating adequate adherence to perform in vivo assays. Biseugenol (20 mg·kg−1) was thus administered intraperitoneally (four days of treatment) and resulted in a significant reduction in both eosinophils and neutrophils of bronchoalveolar lavage fluid in ovalbumin-sensitized mice with no statistical difference from dexamethasone (5 mg·kg−1). As for lung function parameters, biseugenol (20 mg·kg−1) significantly reduced airway and tissue damping in comparison to ovalbumin group, with similar efficacy to positive control dexamethasone. Airway hyperresponsiveness to intravenous methacholine was reduced with biseugenol but was inferior to dexamethasone in higher doses. In conclusion, biseugenol displayed antiasthmatic effects, as observed through the reduction of inflammation and airway hyperresponsiveness, with similar effects to dexamethasone, on mixed-granulocytic ovalbumin-sensitized miceen
dc.description.provenanceSubmitted by Carla Prado (carla.prado@unifesp.br) on 2021-04-01T19:10:01Z No. of bitstreams: 1 MOLECULES biseugenol e asma - VITOR PONCI-2020-.pdf: 2289674 bytes, checksum: 73bf29191646aedcc6036f37c87c8660 (MD5)en
dc.description.provenanceApproved for entry into archive by Diogo Misoguti (diogo.misoguti@unifesp.br) on 2021-04-01T19:35:22Z (GMT) No. of bitstreams: 1 MOLECULES biseugenol e asma - VITOR PONCI-2020-.pdf: 2289674 bytes, checksum: 73bf29191646aedcc6036f37c87c8660 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-04-01T19:35:22Z (GMT). No. of bitstreams: 1 MOLECULES biseugenol e asma - VITOR PONCI-2020-.pdf: 2289674 bytes, checksum: 73bf29191646aedcc6036f37c87c8660 (MD5) Previous issue date: 18-11-20en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 2018/06088-0pt_BR
dc.format.extent1-13pt_BR
dc.identifierhttps://doi.org/10.3390/molecules25225384
dc.identifier.citationPonci V, Silva RC, Santana FPR, Grecco SS, Fortunato CRM, Oliveira MA, Tavares-de-Lima W, Olivo CR, Tibério IdFLC, Gomes KS, Prado CM, Lago JHG. Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma. Molecules. 2020; 25(22):5384. https://doi.org/10.3390/molecules25225384pt_BR
dc.identifier.doi10.3390/molecules25225384pt_BR
dc.identifier.issn1420-3049pt_BR
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/60803
dc.languageengpt_BR
dc.publisherProf. Dr. R. Daniel Littlept_BR
dc.relation.ispartofMoleculespt_BR
dc.rightsAcesso abertopt_BR
dc.subjectBiseugenolen
dc.subjectMixed-granulocytic asthmaen
dc.subjectAirway responsivenessen
dc.subjectAirway inflammationen
dc.titleBiseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthmapt_BR
dc.typeArtigopt_BR
unifesp.campusInstituto de Saúde e Sociedade (ISS)pt_BR
unifesp.departamentoBiociênciaspt_BR
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
MOLECULES biseugenol e asma - VITOR PONCI-2020-.pdf
Tamanho:
2.18 MB
Formato:
Adobe Portable Document Format
Descrição:
Artigo principal
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
license.txt
Tamanho:
5.35 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
ISS - Artigos