Avaliação do estado nutricional de folato, vitamina B12 e estado cognitivo em idosos acompanhados pelo estudo de coorte da Vila Clementino, EPIDOSO
Data
2020-01-27
Orientadores
Tomita, Luciana Yuki 
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: Investigar o estado nutricional de folato (fo) e vitamina B12 (B12) e a sua
relação com o estado cognitivo entre idosos residentes no município de São
Paulo. Métodos: Estudo transversal, com dados da linha de base do ensaio clínico
em idosos de maio/2018 a junho/2019. Foram incluídos idosos sem demência ou
demência questionável e sem depressão. Concentrações séricas de B12, fo total,
sérico e eritrocitário foram determinadas. Calculou-se as medidas de tendência central
e dispersão e empregou-se testes x2 ou exato de Fisher, teste t de Student ou Mann-
Whitney com nível de significância de 5%. Os fatores associados à concentração
sanguínea de fo sérico, eritrocitário, total e B12 foram identificados pelo modelo de
regressão linear múltipla. Análise de regressão logística para avaliar fatores
associados ao Comprometimento Cognitivo Leve (CCL). Resultados: Avaliou-se 169
idosos, 78% mulheres, idade média (DP) de 75,6 (7,3) anos e renda per
capita mediana (P25, P75) de R$2750,00 (1500; 4300). Prevalências de deficiência
de fo sérico, eritrocitário e B12 sérica foram, respectivamente, 13%, 27% e 5%. Mais
da metade reportou consumo inadequado de fo e cerca de 20% de B12. Fatores
associados ao fo eritrocitário foram: Índice de Massa Corporal (IMC), continuar
trabalhando, uso de medicamento, deficiência de B12, consumo de colesterol,
carboidrato, zinco, cálcio e magnésio (R2 ajustado=13,8%). Fatores associados ao fo
total foram: IMC, continuar trabalhando, uso de medicamento, deficiência de B12, dieta
rica em colesterol, carboidrato e zinco (R2 ajustado=9,8%). Com relação à B12 foram: uso
de prótese, IMC, sedentarismo, fo eritrocitário, CCL e não receber aposentadoria,
consumo de álcool, vitamina D e selênio (R2 ajustado=15,4%). Fatores associados
positivamente ao CCL foram: idade e menor nível de escolaridade e, negativamente,
ser mulher e maior consumo de tiamina. Conclusão: A deficiência de fo sérico,
eritrocitário e B12 sérica foi baixa. Mais de 50% reportou consumo inadequado de fo e
20% de B12. Foi encontrada uma associação negativa entre B12 e CCL.
Objective: To investigate the nutritional status of folate (fo) and vitamin B12 (B12) and association with cognitive status among elderly living in São Paulo city. Methods: Cross-sectional study using baseline data from the clinical trial of elderly individuals, with data from May/2018 until June/2019. Inclusion criteria: elderly individuals without dementia or questionable dementia and without depression. Serum B12, total, serum and red blood cell (RBC) fo were analyzed. Measures of central tendency and of dispersion, x2 test or Fisher’s exact test, Student’s t-test or Mann-Whitney’s were used with significance level of 5%. Associated factors of blood concentrations of serum, RBC and total fo, as well as with B12 were identified by multiple regression model. Logistic regression model was applied to evaluate associated factors to Mild Cognitive Impairment (MCI). Results: 169 participants, 78% female, with mean (SD) age 75.6 years (7.3), and median per capita income (IQR) of R$2750.00 (1500; 4300). Prevalence of deficiency of serum fo, RBC fo and B12 were, respectively, 13%, 27% and 5%. Over half reported inadequate intake of fo and approximately 20% of B12. Associated factors of RBC fo were: Body Mass Index (BMI), continue working, medication use, B12 deficiency, intake of cholesterol, carbohydrate, zinc, calcium and magnesium (R2 adjusted=13.8%). Associated factors of total fo were BMI, continue working, medication use, B12 deficiency, high intake of cholesterol, carbohydrate and zinc (R2 adjusted =9.8%). Associated factors of B12 were use of dental prosthesis, BMI, sedentary lifestyle, RBC fo, MCI, not receiving social security retirement benefit, intake of alcohol, vitamin D and selenium (R2 adjusted =15.4%). Positive associated factors of MCI were age and lower education level, whereas being female and high intake of thiamine were negatively associated. Conclusion: Most of elders did not present deficiency of serum fo, RBC fo and serum B12. More than 50% reported inadequate intake of fo, and 20% of B12. A negative association was found between B12 and MCI.
Objective: To investigate the nutritional status of folate (fo) and vitamin B12 (B12) and association with cognitive status among elderly living in São Paulo city. Methods: Cross-sectional study using baseline data from the clinical trial of elderly individuals, with data from May/2018 until June/2019. Inclusion criteria: elderly individuals without dementia or questionable dementia and without depression. Serum B12, total, serum and red blood cell (RBC) fo were analyzed. Measures of central tendency and of dispersion, x2 test or Fisher’s exact test, Student’s t-test or Mann-Whitney’s were used with significance level of 5%. Associated factors of blood concentrations of serum, RBC and total fo, as well as with B12 were identified by multiple regression model. Logistic regression model was applied to evaluate associated factors to Mild Cognitive Impairment (MCI). Results: 169 participants, 78% female, with mean (SD) age 75.6 years (7.3), and median per capita income (IQR) of R$2750.00 (1500; 4300). Prevalence of deficiency of serum fo, RBC fo and B12 were, respectively, 13%, 27% and 5%. Over half reported inadequate intake of fo and approximately 20% of B12. Associated factors of RBC fo were: Body Mass Index (BMI), continue working, medication use, B12 deficiency, intake of cholesterol, carbohydrate, zinc, calcium and magnesium (R2 adjusted=13.8%). Associated factors of total fo were BMI, continue working, medication use, B12 deficiency, high intake of cholesterol, carbohydrate and zinc (R2 adjusted =9.8%). Associated factors of B12 were use of dental prosthesis, BMI, sedentary lifestyle, RBC fo, MCI, not receiving social security retirement benefit, intake of alcohol, vitamin D and selenium (R2 adjusted =15.4%). Positive associated factors of MCI were age and lower education level, whereas being female and high intake of thiamine were negatively associated. Conclusion: Most of elders did not present deficiency of serum fo, RBC fo and serum B12. More than 50% reported inadequate intake of fo, and 20% of B12. A negative association was found between B12 and MCI.
Descrição
Citação
LIU, Â.S.L.W. Avaliação do estado nutricional de folato, vitamina B12 e estado cognitivo em idosos acompanhados pelo estudo de coorte da Vila Clementino, EPIDOSO. São Paulo, 2020. 110 p.
Dissertação (Mestrado em Saúde Coletiva) – Universidade Federal de São Paulo, 2020.