Inércia clínica na intensificação da terapia com insulina em pacientes com Diabetes mellitus tipo 2 de um centro de diabetes público, terciário e com limitações no arsenal terapêutico farmacológico

Inércia clínica na intensificação da terapia com insulina em pacientes com Diabetes mellitus tipo 2 de um centro de diabetes público, terciário e com limitações no arsenal terapêutico farmacológico

Author Alvarenga, Marcelo Alves Autor UNIFESP Google Scholar
Advisor Chacra, Antonio Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Graduate program Medicina (Endocrinologia e Metabologia)
Abstract Background: Clinical inertia is related to the difficulty of achieving and maintaining optimal glycemic control. It has been extensively studied the delay of the period to insulin introduction in type 2 diabetes mellitus (T2DM) patients. This study aims to evaluate clinical inertia of insulin treatment intensification in a group of T2DM patients followed at a tertiary public Diabetes Center with limited pharmacologic armamentarium (Metformin, Sulphonylurea and Human Insulin). Methods: This is a real life retrospective record based study with T2DM patients. Demographic, clinical and laboratory characteristics were reviewed. Clinical inertia was considered when the patients did not achieve the individualized glycemic goals and there were no changes on insulin daily dose in the period. Results: We studied 323 T2DM patients on insulin therapy (plus Metformin and or Sulphonylurea) for a period of 2 years. The insulin daily dose did not change in the period and the glycated hemoglobin (A1c) ranged from 8.8 + 1.8% to 8.7 + 1.7% (basal vs 1st year; ns) and to 8.5 + 1.8% (basal vs 2nd year; p = 0.035). The clinical inertia prevalence was 65.8% (basal), 61.9% (after 1 year) and 58.2% (after 2 years; basal vs 1st year vs 2nd year; ns). In a subgroup of 100 patients, we also studied the first 2 years after insulin introduction. The insulin daily dose ranged from 0.22 + 0.12 to 0.32 + 0.24 IU/kg of body weight/day (basal vs 1st year; p < 0.001) and to 0.39 + 0.26 IU/kg of body weight/day (basal vs 2nd year; p < 0.05). The A1c ranged from 9.6 + 2.1% to 8.6 + 2% (basal vs 1st year; p < 0.001) and to 8.7 + 1.7% (1st year vs 2nd year; ns). The clinical inertia prevalence was 78.5% (at the moment of insulin therapy introduction), 56.2% (after 1 year; p = 0.001) and 62.2% (after 2 years; ns). Conclusion: Clinical inertia prevalence ranged from 56.2% to 78.5% at different moments of the insulin therapy (first 2 years and long term) of T2DM patients followed at a tertiary public Diabetes Center from an upper-middle income country with limited pharmacologic armamentarium.

Em uma população de pacientes com Diabetes Mellitus tipo 2 sob terapia com insulina, acompanhados no Centro de Diabetes da UNIFESP, um centro universitário, público e terciário, com arsenal farmacológico limitado, a porcentagem de pacientes que atingiram os alvos glicêmicos (individualmente ajustados, de acordo com a idade e a presença de comorbidades) variou entre 21,5% e 43,8%. Houve diferença estatística nas doses diárias de insulina, com impacto em redução dos valores de A1c somente no primeiro ano após a introdução da insulina e nenhuma diferença estatística nas doses diárias de insulina em anos subsequentes, apesar de níveis elevados de A1c. Portanto, concluimos que a prevalência de inércia clínica variou de 56,2% a 78,5% em diferentes momentos da terapia com insulina (primeiros 2 anos após a introdução e a longo prazo).
Keywords Type 2 Diabetes Mellitus
Diabetes Complications
Glycosylated Hemoglobin (HbA1c)
Insulin Therapy
Diabetes Mellitus Tipo 2
Complicações Do Diabetes
Hemoglobina Glicosilada (HbA1c)
Terapia Com Insulina
Language Portuguese
Date 2019-02-28
Research area Diagnóstico E Terapêutica
Knowledge area Endocrinologia E Metabologia
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 170 p.
Origin https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7610354
Access rights Closed access
Type Dissertation
URI https://repositorio.unifesp.br/handle/11600/59242

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