The dual effect of paradoxical sleep deprivation on murine immune functions

The dual effect of paradoxical sleep deprivation on murine immune functions

Author Sa-Nunes, Anderson Google Scholar
Bizzarro, Bruna Google Scholar
Egydio, Flavia Autor UNIFESP Google Scholar
Barros, Michele S. Google Scholar
Sesti-Costa, Renata Google Scholar
Soares, Elyara M. Google Scholar
Pina, Adriana Google Scholar
Russo, Momtchilo Google Scholar
Faccioli, Lucia H. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Abstract We aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with thioglycollate and exposed to paradoxical sleep deprivation. Sleep-deprived animals presented decreased cell migration compared to controls. Nitric oxide production was reduced in macrophages from sleep-deprived mice compared to controls. Cell surface analysis showed that sleep deprivation reduced F4/80(+)/CD80(low) peritoneal cell population induced by thioglycollate injection. Sleep-deprived mice were not more susceptible to infection than control mice. Our findings challenge the general perception that sleep loss always increases infection susceptibility. (C) 2015 Elsevier B.V. All rights reserved.
Keywords Sleep
Inflammation
Macrophages
Immune response
Trypanosoma cruzi
Histoplasma capsulatum
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2012/21501-5
CNPq: 305509/2012-8
CNPq: 305177/2013-3
Date 2016
Published in Journal Of Neuroimmunology. Amsterdam, v. 290, p. 9-14, 2016.
ISSN 0165-5728 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 9-14
Origin https://doi.org/10.1016/j.jneuroim.2015.11.013
Access rights Closed access
Type Article
Web of Science ID WOS:000368955000002
URI https://repositorio.unifesp.br/handle/11600/58553

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