The dual effect of paradoxical sleep deprivation on murine immune functions

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dc.citation.volume290
dc.contributor.authorSa-Nunes, Anderson
dc.contributor.authorBizzarro, Bruna
dc.contributor.authorEgydio, Flavia [UNIFESP]
dc.contributor.authorBarros, Michele S.
dc.contributor.authorSesti-Costa, Renata
dc.contributor.authorSoares, Elyara M.
dc.contributor.authorPina, Adriana
dc.contributor.authorRusso, Momtchilo
dc.contributor.authorFaccioli, Lucia H.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-10-30T18:46:39Z
dc.date.available2020-10-30T18:46:39Z
dc.date.issued2016
dc.description.abstractWe aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with thioglycollate and exposed to paradoxical sleep deprivation. Sleep-deprived animals presented decreased cell migration compared to controls. Nitric oxide production was reduced in macrophages from sleep-deprived mice compared to controls. Cell surface analysis showed that sleep deprivation reduced F4/80(+)/CD80(low) peritoneal cell population induced by thioglycollate injection. Sleep-deprived mice were not more susceptible to infection than control mice. Our findings challenge the general perception that sleep loss always increases infection susceptibility. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Ave Prof Lineu Prestes 1730-ICB 4, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Rua Botucatu 862, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Rua Botucatu 862, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDFAPESP: 2012/21501-5
dc.description.sponsorshipIDCNPq: 305509/2012-8
dc.description.sponsorshipIDCNPq: 305177/2013-3
dc.format.extent9-14
dc.identifierhttps://doi.org/10.1016/j.jneuroim.2015.11.013
dc.identifier.citationJournal Of Neuroimmunology. Amsterdam, v. 290, p. 9-14, 2016.
dc.identifier.doi10.1016/j.jneuroim.2015.11.013
dc.identifier.issn0165-5728
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58553
dc.identifier.wosWOS:000368955000002
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Neuroimmunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSleepen
dc.subjectInflammationen
dc.subjectMacrophagesen
dc.subjectImmune responseen
dc.subjectTrypanosoma cruzien
dc.subjectHistoplasma capsulatumen
dc.titleThe dual effect of paradoxical sleep deprivation on murine immune functionsen
dc.typeinfo:eu-repo/semantics/article
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