Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients

Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients

Author Negri, Clara E. Autor UNIFESP Google Scholar
Goncalves, Sarah S. Google Scholar
Sousa, Ana Cristina P. Autor UNIFESP Google Scholar
Bergamasco, Maria Daniela Autor UNIFESP Google Scholar
Martino, Marines D. V. Google Scholar
Queiroz-Telles, Flavio Google Scholar
Aquino, Valerio Rodrigues Google Scholar
Castro, Paulo de Tarso O. Google Scholar
Hagen, Ferry Google Scholar
Meis, Jacques F. Google Scholar
Colombo, Arnaldo L. Autor UNIFESP Google Scholar
Abstract Aspergillus fumigatus azole resistance has emerged as a global health problem. We evaluated the in vitro antifungal susceptibility of 221 clinical A. fumigatus isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for CYP51A mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.
Keywords A. fumigatus
invasive aspergillosis
triazole resistance
antifungal resistance
Brazil
xmlui.dri2xhtml.METS-1.0.item-coverage Washington
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil (CNPq)
CAPES-PROEX
CAPES-PDSE
CAPES, Brazil
CAPES-DS
Astellas
Basilea
Merck
United Medical
Gilead Sciences
CNPQ
Gilead
Pfizer
Grant number CAPES: AUX-PE-PNPD-2312/2011
FAPESP: 2012/01138-4
CNPq: 307510/2015-8
CAPES-PDSE: 99999.008426/2014-07
CAPES: PNPD 23038.007393/2011-1109
Date 2017
Published in Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 11, p. -, 2017.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent -
Origin http://dx.doi.org/10.1128/AAC.00608-17
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000413558300027
URI https://repositorio.unifesp.br/handle/11600/58281

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