Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients

Página do item simplificado
dc.citation.issue11
dc.citation.volume61
dc.contributor.authorNegri, Clara E. [UNIFESP]
dc.contributor.authorGoncalves, Sarah S.
dc.contributor.authorSousa, Ana Cristina P. [UNIFESP]
dc.contributor.authorBergamasco, Maria Daniela [UNIFESP]
dc.contributor.authorMartino, Marines D. V.
dc.contributor.authorQueiroz-Telles, Flavio
dc.contributor.authorAquino, Valerio Rodrigues
dc.contributor.authorCastro, Paulo de Tarso O.
dc.contributor.authorHagen, Ferry
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorColombo, Arnaldo L. [UNIFESP]
dc.coverageWashington
dc.date.accessioned2020-09-01T13:21:28Z
dc.date.available2020-09-01T13:21:28Z
dc.date.issued2017
dc.description.abstractAspergillus fumigatus azole resistance has emerged as a global health problem. We evaluated the in vitro antifungal susceptibility of 221 clinical A. fumigatus isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for CYP51A mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Infectol, Lab Especial Micol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Espirito Santo, Dept Patol, CIMM, Vitoria, ES, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Hosp Clin, Dept Publ Hlth, Div Infect Dis, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Canc Barretos, Sao Paulo, Brazil
dc.description.affiliationCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
dc.description.affiliationCtr Expertise Mycol Radboudumc CWZ, Nijmegen, Netherlands
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Infectol, Lab Especial Micol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil (CNPq)
dc.description.sponsorshipCAPES-PROEX
dc.description.sponsorshipCAPES-PDSE
dc.description.sponsorshipCAPES, Brazil
dc.description.sponsorshipCAPES-DS
dc.description.sponsorshipAstellas
dc.description.sponsorshipBasilea
dc.description.sponsorshipMerck
dc.description.sponsorshipUnited Medical
dc.description.sponsorshipGilead Sciences
dc.description.sponsorshipCNPQ
dc.description.sponsorshipGilead
dc.description.sponsorshipPfizer
dc.description.sponsorshipIDCAPES: AUX-PE-PNPD-2312/2011
dc.description.sponsorshipIDFAPESP: 2012/01138-4
dc.description.sponsorshipIDCNPq: 307510/2015-8
dc.description.sponsorshipIDCAPES-PDSE: 99999.008426/2014-07
dc.description.sponsorshipIDCAPES: PNPD 23038.007393/2011-1109
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1128/AAC.00608-17
dc.identifier.citationAntimicrobial Agents And Chemotherapy. Washington, v. 61, n. 11, p. -, 2017.
dc.identifier.doi10.1128/AAC.00608-17
dc.identifier.issn0066-4804
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58281
dc.identifier.wosWOS:000413558300027
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofAntimicrobial Agents And Chemotherapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectA. fumigatusen
dc.subjectinvasive aspergillosisen
dc.subjecttriazole resistanceen
dc.subjectantifungal resistanceen
dc.subjectBrazilen
dc.titleTriazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patientsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos