Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder

Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder

Author Martins Okuda, Paola Matiko Autor UNIFESP Google Scholar
Klaiman, Cheryl Google Scholar
Bradshaw, Jessica Google Scholar
Reid, Morganne Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Abstract Aim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (omega = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.
Keywords autism spectrum disorder
risk of bias
confirmatory factor analysis
randomized controlled trials
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Sao Paulo Research Foundation-FAPESP
Grant number FAPESP: 2015/04619-0
Date 2017
Published in Frontiers In Psychiatry. Lausanne, v. 8, p. -, 2017.
ISSN 1664-0640 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000416410200001

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