Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder

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dc.citation.volume8
dc.contributor.authorMartins Okuda, Paola Matiko [UNIFESP]
dc.contributor.authorKlaiman, Cheryl
dc.contributor.authorBradshaw, Jessica
dc.contributor.authorReid, Morganne
dc.contributor.authorCogo-Moreira, Hugo [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-09-01T13:21:16Z
dc.date.available2020-09-01T13:21:16Z
dc.date.issued2017
dc.description.abstractAim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (omega = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationChildrens Healthcare Atlanta, Marcus Autism Ctr, Atlanta, GA USA
dc.description.affiliationEmory Univ, Sch Med, Atlanta, GA USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation-FAPESP
dc.description.sponsorshipIDFAPESP: 2015/04619-0
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fpsyt.2017.00265
dc.identifier.citationFrontiers In Psychiatry. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fpsyt.2017.00265
dc.identifier.fileWOS000416410200001.pdf
dc.identifier.issn1664-0640
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58159
dc.identifier.wosWOS:000416410200001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautism spectrum disorderen
dc.subjectrisk of biasen
dc.subjectconfirmatory factor analysisen
dc.subjectmeta-analysisen
dc.subjectrandomized controlled trialsen
dc.titleAssessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorderen
dc.typeinfo:eu-repo/semantics/article
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