The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

Author Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Rios, Adiel C. Autor UNIFESP Google Scholar
Nunes, Sandra O. V. Google Scholar
Barbosa, Decio Sabbatini Google Scholar
Sethi, Sumit Autor UNIFESP Google Scholar
Zeni, Maiara Autor UNIFESP Google Scholar
Mansur, Rodrigo B. Google Scholar
Maes, Michael Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age-associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor kappa B, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Oxidative stress
Accelerated aging
Major depressive disorder
Clinical implications
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Science without Borders-Level A
coordination of Improvement of Higher Education Personnel (CAPES)
National Counsel of Technological and Scientific Development (CNPq), Brazil
Date 2016
Published in Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 65, p. -, 2016.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent -
Access rights Closed access
Type Article
Web of Science ID WOS:000366709200015

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