The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

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dc.citation.volume65
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorRios, Adiel C. [UNIFESP]
dc.contributor.authorNunes, Sandra O. V.
dc.contributor.authorBarbosa, Decio Sabbatini
dc.contributor.authorSethi, Sumit [UNIFESP]
dc.contributor.authorZeni, Maiara [UNIFESP]
dc.contributor.authorMansur, Rodrigo B.
dc.contributor.authorMaes, Michael
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-08-21T17:00:24Z
dc.date.available2020-08-21T17:00:24Z
dc.date.issued2016
dc.description.abstractMajor depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age-associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor kappa B, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida, India
dc.description.affiliationUniv Tubingen, Dept Psychiat, Clin Psychiat & Psychotherapy, Tubingen, Germany
dc.description.affiliationUniv Estadual Londrina, Grad Program Hlth Sci, Londrina, PR, Brazil
dc.description.affiliationUniv Toronto, MDPU, UHN, Toronto, ON, Canada
dc.description.affiliationChulalongkorn Univ, Dept Psychiat, Bangkok, Thailand
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipScience without Borders-Level A
dc.description.sponsorshipcoordination of Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq), Brazil
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2015.08.016
dc.identifier.citationProgress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 65, p. -, 2016.
dc.identifier.doi10.1016/j.pnpbp.2015.08.016
dc.identifier.issn0278-5846
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57984
dc.identifier.wosWOS:000366709200015
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectOxidative stressen
dc.subjectAccelerated agingen
dc.subjectMajor depressive disorderen
dc.subjectClinical implicationsen
dc.titleThe role of oxidative and nitrosative stress in accelerated aging and major depressive disorderen
dc.typeinfo:eu-repo/semantics/article
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