Physical exercise, neuroplasticity, spatial learning and memory
Cassilhas, Ricardo Cardoso [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de
Is part ofCellular And Molecular Life Sciences
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There has long been discussion regarding the positive effects of physical exercise on brain activity. However, physical exercise has only recently begun to receive the attention of the scientific community, with major interest in its effects on the cognitive functions, spatial learning and memory, as a non-drug method of maintaining brain health and treating neurodegenerative and/or psychiatric conditions. In humans, several studies have shown the beneficial effects of aerobic and resistance exercises in adult and geriatric populations. More recently, studies employing animal models have attempted to elucidate the mechanisms underlying neuroplasticity related to physical exercise-induced spatial learning and memory improvement, even under neurodegenerative conditions. In an attempt to clarify these issues, the present review aims to discuss the role of physical exercise in the improvement of spatial learning and memory and the cellular and molecular mechanisms involved in neuroplasticity.
CitationCellular And Molecular Life Sciences. Basel, v. 73, n. 5, p. 975-983, 2016.
SponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Department of Physical Education - Universidade Federal dos Vales do Jequit-inhonha e Mucuri (UVFJM)
School of Physical Education, Physiotherapy and Occupational Therapy (EEFFTO) - Universidade Federal de Minas Gerais (UFMG)
Department of Psychobiology Universidade Federal de Sao Paulo (UNIFESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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